Paving the way globally in microbial efficacy, we have the most comprehensive portfolio of efficacy testing in ultrasound probe
high level disinfection (HLD).

We go further…


Nanosonics conducts extensive laboratory testing, focused on continually validating the effectiveness of trophon. Patient safety and reducing the risk of infection spread is paramount to us and drives our clinical research and testing.

Going far beyond the minimum regulatory requirements, we prioritise having the broadest possible microbial efficacy program. This absolute dedication to going further really sets us apart and ensures we exceed standards in HLD.

trophon is a pioneer globally in microbial efficacy, the first HLD system in the world proven to kill native, infectious, high-risk HPV.1

    • trophon inactivates the mandated subset of microorganisms, as required by European Standards.
    • trophon is proven to also eliminate an extended range of clinically infectious pathogens that other HLD products do not, including:*

– Sexually Transmitted Infections (STIs)

Clostridium difficile spores

– Drug resistant bacteria

1. Ryndock E, Robison R, Meyers C. Susceptibility of HPV16 and 18 to high level disinfectants indicated for semi-critical ultrasound probes. J Med Virol. 2016;88(6):1076-80.

Sexually Transmitted Infections (STIs) testing

Ultrasound probes frequently contact body sites where STIs can occur. trophon is proven to completely inactivate a range of STI causing pathogens.*


HIV


Human immunodeficiency virus (HIV) is an incurable disease that affects the immune system, impairing its ability to fight disease.





HIV

More than 100,000 people in the UK are estimated to have HIV, with 6,095 new HIV diagnoses and 613 HIV-related deaths reported in 2015. 4, 5

trophon has been shown to inactivate HIV in laboratory tests.

Hepatitis B


Hepatitis B (HBV) infection attacks the liver and can be transmitted through body fluids (e.g. during sexual contact).





Hepatitis B


About 11,708 confirmed hepatitis B cases were reported in England and Wales in 2015, of which 83% were chronic cases.6

trophon is effective against hepatitis B on ultrasound probes.



Hepatitis C


Hepatitis C virus (HCV) is a blood borne virus that can cause chronic infection and liver diseases like liver cancer.





Hepatitis C


it is estimated that more than 15 million people in Europe and approximately 214,000 people in the UK have chronic hepatitis C infection.7
trophon is effective against hepatitis C on ultrasound probes.




HPV


HPV is one of the most commonly diagnosed sexually transmitted infections and can cause cancer in both sexes.1,2




HPV

Causes 99.7% of cervical cancer cases, 88% of anal cancers, 70% of vaginal cancer cases and 50% of penile cancers. 2,8

Genital warts (caused by HPV infection) is the second most common STI in England.9
trophon is effective against HPV on ultrasound probes.

Chlamydia


Chlamydia trachomatis is the most common sexually transmitted infection in the UK3 and can result in infertility and ectopic pregnancy.



Chlamydia trachomatis

Chlamydia infections accounted for 46% of all STIs in 2015, with the highest incidence in young people aged 15-24.3
trophon is effective against Chlamydia trachomatis.

Gonorrhea


Neisseria gonorrhoeae is a sexually transmitted disease that infects both women and men and, if left untreated, can lead to infertility.




Gonorrhea

Gonorrhea diagnoses in England decreased between 2015 and 2016 (after a 175% increase from 2008-2015), however sustained transmission is of concern with the recent emergence of antimicrobial resistant strains of Neisseria gonorrhoeae.10
trophon is effective against gonorrhoea on ultrasound probes.

 

Candida


Candida albicans can cause fungal infection in the throat and vagina as well as cause bloodstream infections resulting in high rates of morbidity and mortality.




Candida

Candida spp. accounted for 5.5% of ICU-acquired pneumonia and 8.6% of ICU-acquired bloodstream infections in the UK in 2012.11
trophon is effective against Candida on ultrasound probes.

 
1. Public Health England. Genital warts and human papillomavirus (HPV): guidance, data and analysis. Website updated 7 October 2016. https://www.gov.uk/government/collections/genital-warts-and-human-papillomavirus-hpv-guidance-data-and-analysis . Accessed 21 June 2017.

2. Taylor S, Bunge E, Bakker M, Castellsagué X. The incidence, clearance and persistence of non-cervical human papillomavirus infections: a systematic review of the literature. BMC Infectious Diseases. 2016;16:293.

3. Public Health England. The surveillance, epidemiology, screening and prevention of chlamydia. Infectious Diseases Collection – Chlamydia: surveillance, data, screening and management. Updated 26 February 2016. https://www.gov.uk/government/collections/chlamydia-surveillance-data-screening-and-management#epidemiology. Accessed 16 Mar 2017.

4. Public Health England. HIV diagnoses, late diagnoses and numbers accessing treatment and
care: 2016 Report. Version 1. Published October 2016.

5. Terrence Higgins Trust, HIV in the UK. http://www.tht.org.uk/our-charity/Facts-and-statistics-about-HIV/HIV-in-the-UK. Accessed 19 Apr 2017.

6. Public Health England. Acute hepatitis B (England): annual report for 2015. Health Protection Reports – Infection Reports/Immunisation. Vol. 10 No. 28. 26 August 2016.

7. Public Health England/Health Protection Scotland/Public Health Wales/HSC. Hepatitis C in the UK: 2016 Report. Working towards its elimination as a major public health threat. Published July 2016. PHE publications gateway number: 2016151.

8. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. The Journal of pathology. 1999;189(1):12-9.

9. NHS Choices. What is HPV? NHS Choices – Common Health Questions. Updated 15 December 2015. http://www.nhs.uk/chq/pages/2611.aspx. Accessed 15 Mar 2017.

10. Public Health England. Sexually transmitted infections and chlamydia screening in England, 2015. Health Protection report (weekly report): Infection report. Vol 11 No. 20. 9 June 2017.

11. European Centre for Disease Prevention and Control. Annual epidemiological report 2014. Antimicrobial resistance and healthcare-associated infections. Stockholm: ECDC; 2015. http://ecdc.europa.eu/en/publications/Publications/antimicrobial-resistance-annual-epidemiological-report.pdf. Accessed 17 Mar 2017.

* Nanosonics internal test data.


Bacterial spores testing

Bacterial spores are extremely resistant to disinfectants. In addition to achieving high level disinfection, trophon is effective against bacterial endospores in accordance with European Standards. trophon is effective against Clostridium difficile spores which contribute significantly to the Hospital Acquired Infection burden and cause severe diarrhoea in infected individuals.


Sporicidal


Bacterial spores are extremely resistant to disinfectants. High level disinfectants are only required to be sporidical at extended contact times.





Sporicidal

Spores like Clostridium difficile can cause severe diarrhoea and is a leading contributor to the Hospital Acquired Infection burden in our healthcare systems.

 

C.diff


Clostridium difficile is a common Hospital Acquired Infection (HAI) characterised by severe diarrhoea. It is a leading contributor to the HAI burden in our healthcare systems.




C.diff

In the UK there were 12,985 reports of C. difficile in 2014, with the majority of cases (74.1%) occurring in age groups 65 years and over.1

1. Public Health England. Voluntary surveillance of Clostridium difficile, England, Wales and Northern Ireland: 2014. Health Protection report (weekly report): Infection report. Vol 9 No. 21. 19 June 2015.

Drug resistant bacteria testing

Drug resistant bacteria outbreaks in healthcare facilities are a real threat and antibiotics are ineffective against these strains. trophon inactivates these drug resistant bacteria.*


MRSA


Methicillin-resistant Staphylococcus aureus is antibiotic resistant and a common cause of many HAIs.





MRSA

Infection with MRSA can cause skin infections and can lead to more severe diseases including sepsis, pneumonia and bloodstream infections. trophon is effective against MRSA.

VRE


Vancomycin-resistant Enterococci (VRE) have resistance to one of the last resort antibiotics available.1




VRE

Enterococci reside in the gut and symptoms can be severe. Infection can occur from contaminated healthcare settings. trophon is effective against VRE.

CRE


Infection with Carbapenem-resistant enterobacteriaceae (CRE) can cause severe morbidity and death.





CRE

A wave of CRE outbreaks were associated with duodenoscopes in the USA and EU between 2013 and 2015 resulted in hundreds of patient deaths.2,3 trophon is effective against CRE.

1. Reed D, Kemmerly SA. Infection Control and Prevention: A Review of Hospital-Acquired Infections and the Economic Implications. The Ochsner Journal. 2009;9(1):27-31.

2. Rubin ZA, Murthy RK. Outbreaks associated with duodenoscopes: new challenges and controversies. Curr Opin Infect Dis. 2016;29(4):407-14.

3. O’Horo JC, Farrell A, Sohail MR, Safdar N. Carbapenem-resistant Enterobacteriaceae and endoscopy: An evolving threat. Am J Infect Control. 2016; 44(9):1032-6.

* Nanosonics internal test data.


European Standard Testing Requirements

trophon is shown to inactivate all the mandated microorganisms with its seven-minute cycle time when tested according to European Standards. trophon exceeds the minimum requirements for high level disinfection.


Virucidal


Viruses (unlike bacteria) require a host for replication. HLD should inactivate enveloped and non-enveloped viruses.




Virucidal

Viruses can survive in the environment or on surfaces for periods of time. They can be transmitted via air, droplets, body fluids and contact with surfaces.

Mycobactericidal


Mycobacteria can cause serious diseases like tuberculosis. HLD should eliminate mycobacteria within contact time.




Mycobactericidal

Mycobacteria have a tough cell wall and are highly resistant to disinfectants.

Fungicidal


Fungi and yeast are opportunistic pathogens. High level disinfection should be effective against fungi.




Fungicidal

Fungi and yeast can be highly resistant to disinfection. They can take advantage of a change in a patient’s health (e.g. immunocompromised status).

Bactericidal


Vegetative bacteria such as E. Coli cause a wide variety of infectious diseases in healthcare and in the community.




Bactericidal

As per European Standards, all high level disinfectants should demonstrate activity against vegetative bacteria for bactericidal efficacy.

 
 
 

                                                           Organism
Vegetative bacteria Fungi
Carbapenam-resistant Escherichia coli Candida albicans
Enterococcus hirae Aspergillus niger
Methicillin-resistant Staphylococcus aureus Viruses
Neisseria gonorrhoea Adenovirus
Pseudomonas aeruginosa Hepatitis C virus surrogate (Bovine viral diarrhoea virus)
Staphylococcus aureus Human hepatitis B virus surrogate (duck hepatitis B virus)
Vancomycin-resistant Enterococcus Human immunodeficiency virus type 1
Mycobacteria Human papillomavirus (HPV16 and HPV18)
Mycobacterium terrae Polio virus
Mycobacterium avium Chlamydia
Bacterial endospores Chlamydia trachomatis
Bacillus cereus
Bacillus subtilis
Geobacillus stearothermophilus
Clostridium difficile

Proven effective against the widest range of microorganisms,
you can have confidence in trophon.